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| First Name: | Milan | | Last Name: | Fiala | | Title: | Researcher | | Advanced Degrees: | M.D. | | Affiliation: | UCLA/WLAVA | | Department: | Medicine | | Street Address 1: | 615 charles Young Drive South | | Street Address 2: | Room 546 | | City: | Los Angeles | | State/Province: | CA | | Zip/Postal Code: | 90095-1668 | Country/Territory: | U.S.A. | | Phone: | 3102066392 | | Fax: | 3102461321 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 4 May 2009]
consultant for MPBio on diagnostic blood test for Alzheimer disease
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View all comments by Milan Fiala
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Alzheimer Disease, Neuromuscular Disorders (ALS, etc.)
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A-beta PP/A-beta, Apoptosis/Cell cycle, Neuroimmunology, Neuropathology, Diagnosis
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1. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. European Journal of Clinical Investigation (2002) 32: 360-371
2. Fiala M, Cribbs DH, Rosenthal M, Bernard G: Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer’s disease. Journal of Alzheimer’s Disease, 11:1-7, 2007.
3. Milan Fiala, Philip Liu, Araceli Espinosa-Jeffrey, Mark Rosenthal, John Ringman , James Sayre, Laura Zhang, Justin Zaghi, Ben Chiang, Sheila Dejbakhsh, James Hui, Michelle Mahanian, George Bernard, John Cashman. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci (USA) 104: 12849-12854, 2007.
4. Avagyan H., Goldenson B., Masoumi A., Porter V., Wiedau-Pazos M., Sayre J., Ong R, Tse E, Koo P, Bae S, Mahanian M, Micic M, Liu P, Rosenthal M., Fiala M. Immune blood biomarkers of Alzheimer disease patients . Journal of Neuroimmunology, In press 2009 doi. 10.1016/j.jneuroim.2009.02.015
5. Zaghi, Goldenson, Inayathullah, lossinsky, Masoumi, Avagyan, Mahanian, Bernas,Weinand, Tosenthal, Espinosa-Jeffrey, de Vellis, Teplow, Fiala. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathologica 117:111-124, 2009 |
Only few researchers study human patients |
Innate immunity of Alzheimer's disease patients. Our data suggest that innate immune dysfunction is the crucial problem in Alzheimer's disease not reproduced in current models. Research in Alzheimer's disease patients should be the golden yard stick in Alzheimer's disease research. |
Blood-borne macrophages participate in clearance of amyloid-beta in the brain but are defective in amyloid-beta phagocytosis in patients with Alzheimer's disease |
Evidence for macrophage dysfunction is supported by a pilot study (submitted for publication), but more patients with Alzheimer's disease need to be investigated. |
In addition to abnormal innate immunity, patients have evidence of abnormal adaptive immunity. The primary cause seems to be a defect in innate immunity, but this needs to be investigated further |
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